Novel and unexpected role of the sarcolemmal calcium pumps (PMCAs) in the heart
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چکیده
s 58 2010
منابع مشابه
Plasma membrane calcium pumps in mouse olfactory sensory neurons.
We report here the presence of specific plasma membrane calcium pumps (PMCAs) in mouse olfactory sensory neurons. All 4 isoforms are present as shown by deconvolution microscopy, and the specific splice variants are identified by reverse transcriptase (RT)-polymerase chain reaction (PCR). The PMCAs are present on the cell body, dendrite, knob, and cilia, but the different isoforms of PMCAs are ...
متن کاملDefective Calcium Pumps in Neurons in the Aging Brain and in Parkinson’s Disease
The plasma membrane Ca-ATPase (PMCA) pumps play an important role in the maintenance of precise levels of intracellular Ca, quintessential for the optimal functioning and long term survival of neurons. In this paper, we review evidence showing alterations in the PMCAs in aging brain. Additionally, we provide evidence showing defects in these transporters in Parkinson’s disease (PD). PMCA activi...
متن کاملPlasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility.
Plasma-membrane calcium pumps [PMCAs (plasma-membrane Ca(2+)-ATPases)] expel Ca(2+) from eukaryotic cells to maintain overall Ca(2+) homoeostasis and to provide local control of intracellular Ca(2+) signalling. Recent work indicates functional versatility among PMCA isoforms, with specific pumps being essential for cochlear hair cell function, sperm motility, feedback signalling in the heart an...
متن کاملPlasma membrane calcium ATPase proteins as novel regulators of signal transduction pathways.
Emerging evidence suggests that plasma membrane calcium ATPases (PMCAs) play a key role as regulators of calcium-triggered signal transduction pathways via interaction with partner proteins. PMCAs regulate these pathways by targeting specific proteins to cellular sub-domains where the levels of intracellular free calcium are kept low by the calcium ejection properties of PMCAs. According to thi...
متن کاملRole of plasma membrane calcium ATPases in calcium clearance from olfactory sensory neurons.
Odorants cause Ca(2+) to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca(2+) not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca(2+)-dependent adaptation, Ca(2+) must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. ...
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تاریخ انتشار 2010